Leaving EpiPen in car can reduce the concentration of adrenaline

A small study has been carried out in Poland to check the concentration of adrenaline after being left in a hot car.

Official advice is to keep an EpiPen stored below 25 °C (77 °F) and do not expose it to extreme heat.

Study

Nine adult dose EpiPens were left in a car on a hot day:

  • Three were left in the glove compartment;
  • Three in the trunk/boot and;
  • Three on a shelf underneath the rear window.

Each of the EpiPens were placed so that the were not under direct sunlight.

The EpiPens were removed after 12 hours and tested.

Allergy Dog Tags

Results

The solution appearance in all 9 injectors did not have any significant visual changes. They functioned correctly when injected.

When analysed, the adrenaline concentration had reduced in all nine.

 

 

Location Average Reduction in Concentration of Adrenaline
Boot/Trunk 3.3%
Shelf 13.3%
Glove Compartment 14.33%

 

 

 

According to the researchers, these changes are unlikely to make the dose ineffective but further research is needed to see if the exposure is progressive or cumulative, i.e if further exposure to high temperatures could reduce the adrenaline concentration even further.

The study clearly shows the importance of making sure you don’t leave your EpiPen or other adrenlaine auto-injector in your car or in any other place they are likely to get too hot.

Source:

https://www.prweb.com/releases/epipens_may_lose_potency_within_hours_when_stored_in_heated_car/prweb15946824.htm

https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?type=display&setid=7560c201-9246-487c-a13b-6295db04274a#section-13

https://www.medicines.org.uk/emc/files/pil.4289.pdf

http://www.epipen.co.uk/question/how-should-epipenR-be-stored/

http://www.epipen.ie/fileadmin/user_upload/epipen_ie/PDF/12442_Meda_EpiPen_Patient_Brochure_v2.pdf

Disclaimer: The information provided is for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis or treatment. Allergy Lifestyle Limited (t/a) Allergy Lifestyle) uses reasonable endeavours to check the accuracy of information provided however no warranty is given that they are error-free.

Leave a Reply

Your email address will not be published. Required fields are marked *

Translate »